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These medications had powerful anti-inflammatory effects that extended well beyond metabolic improvement

This can be compounded by a testosterone deficiency, which can cause joint instability and lead to increased pain

The 2024 NICE Guideline NG239 from the United Kingdoms National Institute for Health and Care Excellence similarly distinguishes between patients who can be managed with oral therapy and those who require intramuscular treatment

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[5] Safety information: FDA said the available safety information was insufficient to characterize the safety profile for the proposed forms and routes, while reports in the adverse-event database were too limited and confounded to establish causality